Martin Krzywinski

January 2006

Job title and General Description

Scientist – Genome Sciences Centre

I am involved in Fingerprint Mapping. This involves creating fingerprint maps of various genomes, from 1 Mb bacterial genomes to 3 Gb mammalian genomes. So far we have worked on over 20 different organisms, including human, rat, mouse, salmon and poplar. In addition to constructing fingerprint physical maps, we use fingerprints in comparative studies (e.g. different strains of an organism) to verify sequence assemblies and to detect rearrangements in aberrant genomes, e.g. cancer.

My job revolves around the computational aspects of storage, management and analysis of fingerprint data that we generate. I am also involved in writing grant proposals for new projects and manuscripts to document discoveries in scientific journals.

In our study of rearrangements in cancer genomes I work closely with both the laboratory staff and the bioinformatics group.
What specific skills and qualities are needed to do your job?
My job requires an ability to look at the big picture. I must be able to work well independently as well as in a team. As my job involves a lot of problem solving and developing new ideas, I need to be curious and excited by discovery. This job requires the ability to handle the ups and downs of the unknown. I need to be able to handle confusion in order to find the solution to problems and new directions to move the research in.

What do you like most about your work?
I enjoy the uncertainty of my job. I look forward to the new things and the changes. My job has a broad description. It allows me to be creative and experiment with ideas.

What don’t you like about your job?
Sometimes my job leaves me isolated in that I am the only one that knows the issues and projects that I am working through. Because of this I often need to depend on myself to find the answers I’m looking for.

Where do you see your career going from here?
I enjoy the excitement of not knowing what will be next. I like to leave my plans open to follow opportunities as they come up. With the cycle of concept development, grant writing and projects that my job brings there are always new things coming up.

What is the range in salary that comes with your job?
This type of job could range from $60,000-$90,000 depending on experience.

When did you know you wanted to work in sciences?
I have always enjoyed physical sciences. I had summer jobs in various chemistry and physics labs and it felt like a good fit.

What is your educational background? Degrees? Specific courses?
I had a broad range of interests in university. I did two B.Sc. degrees at the University of Ottawa, one in Math and Physics, and another in Biochemistry. At UBC I completed a MSc in Physics working with Medical Imaging. I started at the Genome Sciences Centre as a systems administrator.

What was your favorite course(s) and why?
My favorite course was at the University of Ottawa. It was a course on Statistical Mechanics. It was the first time that I saw how the description of the world at micro-scales (molecules and atoms) relates to the description at macro-scale (you and me). Just like the random movement of molecules results in a well-behaved substance, such as a gas, so do the many complex interactions within a cell result in an organized, higher organism.

What other hobbies and interests do you have?
I really enjoy photography and tinkering with computers. I am involved in the martial art of Aikido as well.

Do you have any advice for young people thinking about getting into your line of work?
Don’t try to fit into a pre-existing job mould. Don’t be afraid to make your own roads. Think of what you enjoy doing on a Sunday afternoon and turn it into a career!